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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: WWOX All Species: 12.12
Human Site: T266 Identified Species: 20.51
UniProt: Q9NZC7 Number Species: 13
    Phosphosite Substitution
    Charge Score: -0.23
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9NZC7 NP_057457.1 414 46677 T266 S S E S H R F T D I N D S L G
Chimpanzee Pan troglodytes XP_001144696 363 41022 L216 C N A A T F A L P W S L T K D
Rhesus Macaque Macaca mulatta XP_001105944 398 45056 A251 Q D V L C R S A P A R V I V V
Dog Lupus familis XP_852623 383 43043 H236 F Q V N H L G H F Y L V Q L L
Cat Felis silvestris
Mouse Mus musculus Q91WL8 414 46494 T266 S S E S H R F T D I N D S S G
Rat Rattus norvegicus NP_001099658 356 40173 C209 V P L H I L V C N A G T F A L
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001505354 146 16628
Chicken Gallus gallus Q5F389 414 46711 T266 S S E S H R F T E I K D S S G
Frog Xenopus laevis NP_001088080 143 16305
Zebra Danio Brachydanio rerio Q803A8 412 46303 T263 S S E S H R F T D L L D S C G
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9VLU5 409 46492 R261 V L S S E S H R F A N L P V E
Honey Bee Apis mellifera XP_395282 414 46992 H259 V I V S S E S H R F S S L R T
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_789399 410 45991 R262 M V S S E S H R F I D F Y S N
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q42536 405 43844 R254 K A N L G D L R G L A G G L N
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 85.5 84.7 82.8 N.A. 93.7 81.1 N.A. 26 83 29.2 71.9 N.A. 48.3 51.2 N.A. 56.2
Protein Similarity: 100 86.2 88.4 87.4 N.A. 96.1 83.8 N.A. 29.4 93 33.3 84.3 N.A. 65.2 66.6 N.A. 73.4
P-Site Identity: 100 0 6.6 13.3 N.A. 93.3 0 N.A. 0 80 0 80 N.A. 13.3 6.6 N.A. 13.3
P-Site Similarity: 100 26.6 13.3 20 N.A. 93.3 6.6 N.A. 0 86.6 0 86.6 N.A. 20 13.3 N.A. 20
Percent
Protein Identity: N.A. N.A. N.A. 28.9 N.A. N.A.
Protein Similarity: N.A. N.A. N.A. 44.6 N.A. N.A.
P-Site Identity: N.A. N.A. N.A. 6.6 N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. 20 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 8 8 8 0 0 8 8 0 22 8 0 0 8 0 % A
% Cys: 8 0 0 0 8 0 0 8 0 0 0 0 0 8 0 % C
% Asp: 0 8 0 0 0 8 0 0 22 0 8 29 0 0 8 % D
% Glu: 0 0 29 0 15 8 0 0 8 0 0 0 0 0 8 % E
% Phe: 8 0 0 0 0 8 29 0 22 8 0 8 8 0 0 % F
% Gly: 0 0 0 0 8 0 8 0 8 0 8 8 8 0 29 % G
% His: 0 0 0 8 36 0 15 15 0 0 0 0 0 0 0 % H
% Ile: 0 8 0 0 8 0 0 0 0 29 0 0 8 0 0 % I
% Lys: 8 0 0 0 0 0 0 0 0 0 8 0 0 8 0 % K
% Leu: 0 8 8 15 0 15 8 8 0 15 15 15 8 22 15 % L
% Met: 8 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 8 8 8 0 0 0 0 8 0 22 0 0 0 15 % N
% Pro: 0 8 0 0 0 0 0 0 15 0 0 0 8 0 0 % P
% Gln: 8 8 0 0 0 0 0 0 0 0 0 0 8 0 0 % Q
% Arg: 0 0 0 0 0 36 0 22 8 0 8 0 0 8 0 % R
% Ser: 29 29 15 50 8 15 15 0 0 0 15 8 29 22 0 % S
% Thr: 0 0 0 0 8 0 0 29 0 0 0 8 8 0 8 % T
% Val: 22 8 22 0 0 0 8 0 0 0 0 15 0 15 8 % V
% Trp: 0 0 0 0 0 0 0 0 0 8 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 8 0 0 8 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _